Which classification includes products with significant abuse potential and accepted medical use?

The classification that includes products with significant abuse potential and accepted medical use is Schedule II. Schedule II drugs are recognized under the Controlled Substances Act and are characterized by their high potential for abuse, which can lead to severe psychological or physical dependence. Despite this potential for abuse, these substances are considered to have accepted medical uses within the United States, contingent on strict regulatory controls.

Examples of Schedule II controlled substances include opioids like morphine and oxycodone, as well as stimulants like amphetamine and methamphetamine, which are used in clinical settings for pain management and attention deficit hyperactivity disorder (ADHD) treatment, respectively. Therefore, while these drugs are effective in medical treatment, their distribution, prescription, and use are closely regulated to minimize the risk of abuse and addiction.

In contrast, Schedule I drugs are deemed to have no accepted medical use and a high potential for abuse, while Schedule III and Schedule IV substances have lower abuse potential and less stringent regulatory controls.